Cancer Cell Line Encyclopedia Proteomics

To date large scale profiling of cell line collections including the cancer cell line encyclopedia ccle has focused primarily on genetic information whereas deep interrogation of the proteome has remained out of reach.
Cancer cell line encyclopedia proteomics. Ccle cancer cell line encyclopedia cclf cancer cell line factory drug repurposing hub prism. Proteins are essential agents of biological processes. The cancer cell line encyclopedia ccle is a catalog of nearly 1 000 human cancer cell lines that have been extensively profiled. 2020 the broad institute of mit harvard.
Quantitative proteomics of the cancer cell line encyclopedia overview. Please see below for a partial list of resources or refer to the list of cancer related data software and tools. Its original release included gene expression dna copy numbers and hybrid capture sequencing. Mass spectrometry based proteomics data is broadly unfamiliar to most biologists in our experience resulting in questions from analysts about how to use the data.
In this publication we expand the cancer cell line encyclopedia to include quantitative proteome profiling by. The average per protein correlation between the proteomics data and rnaseq data was 0 5. Proteins are essential agents of biological processes. You may have been redirected here from the broad cancer program resource gateway which is no longer active.
Quantitative proteomics of the cancer cell line encyclopedia. Cancer cell lines are important model systems to study normal and aberrant cellular processes. Mass spectrometry based proteomics data is broadly unfamiliar to most biologists in our experience resulting in questions from analysts about how to use the data. The cancer cell line encyclopedia ccle is an effort to generate large scale profiling datasets across nearly 1 000 cell lines from diverse tissue lineages.
Over the past decade data from gene expression histone profiling. Gene sets with. Abstract we recently reported the quantitative proteomics of 375 samples as part of the cancer cell line encyclopedia nusinow et al 2020. Abstract we recently reported the quantitative proteomics of 375 samples as part of the cancer cell line encyclopedia nusinow et al 2020.