Cancer Cell Line Encyclopedia Nature

Here we describe the cancer cell line encyclopedia ccle.

Cancer cell line encyclopedia nature. 2012 the cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Pharmacogenomic agreement between two cancer cell line data sets. The cancer cell line encyclopedia is a database of gene expression genotype and drug sensitivity data for human cancer cell lines. 2020 the broad institute of mit harvard.

Cancer cell lines are important model systems to study normal and aberrant cellular processes. Its original release included gene expression dna copy numbers and hybrid capture sequencing. A compilation of gene expression chromosomal copy number and massively parallel sequencing data from 947 human cancer cell lines. The cancer cell line encyclopedia ccle is an effort to generate large scale profiling datasets across nearly 1 000 cell lines from diverse tissue lineages.

The ccle cancer cell line encyclopedia project is a collaboration between the broad institute and the novartis institutes for biomedical research and its genomics institute of the novartis research foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models to develop integrated computational analyses that link distinct pharmacologic vulnerabilities to genomic patterns and to translate cell line integrative genomics into cancer. Here we describe the cancer cell line encyclopedia ccle. Large panels of comprehensively characterized human cancer models including the cancer cell line encyclopedia ccle have provided a rigorous framework with which to study genetic variants. The cancer cell line encyclopedia consortium the genomics of drug sensitivity in cancer consortium.

Abstract large cancer cell line collections broadly capture the genomic diversity of human cancers and provide valuable insight into anti cancer drug response. Nature 528 84 87 2015. Citation s barretina j et al.